>Minoxidil treatment resulted in a 0.22 fold change for 5α-R2 (p < 0.0001). This antiandrogenic effect of minoxidil, shown by significant downregulation of 5α-R2 androgen gene expression in HaCaT cells, may be one of its mechanisms of action in alopecia. pubmed.ncbi.nlm.nih.gov/30064598/
oh nonononono ...
>Although minoxidil has been used for more than two decades to treat androgenetic alopecia (AGA), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may influence the AR or its downstream signaling. These tests revealed that minoxidil suppressed AR-related functions, decreasing AR transcriptional activity in reporter assays, reducing expression of AR targets at the protein level, and suppressing AR-positive LNCaP cell growth. ncbi.nlm.nih.gov/pmc/articles/PMC4039155/
People who use fin or minox to suppress DHT to maintain a girly hairline are playing with biochemical consequences they don't understand
DHT is related to lower systemic inflammation and faster healing of inflammatory response >Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice ncbi.nlm.nih.gov/pmc/articles/PMC7504698/
DHT is associated with lower all-cause mortality, increased lipid synthesis, delayed cognitive decline with age, and significantly lower diabetes risk/insulin resistance >Intracellular DHT is a more potent androgenic agonist than T and increases total serum T. ncbi.nlm.nih.gov/pmc/articles/PMC6459338/
DHT suppresses whole body inflammatory diseases (which range from things like acne to cancer) >Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation ncbi.nlm.nih.gov/pmc/articles/PMC8552015/
DHT robustly increases bone density and skeletal strength >Dihydrotestosterone, a robust promoter of osteoblastic proliferation and differentiation ncbi.nlm.nih.gov/pmc/articles/PMC5651475/
Suppression of DHT is associated with long-term male specific cancers >The Loss of Masculinity With Declined Serum DHT Is Associated With High Risk of Carcinoma in Chinese Men ncbi.nlm.nih.gov/pmc/articles/PMC7339940/
DHT is associated with male neurogenesis and ability to learn new things >Androgens Enhance Adult Hippocampal Neurogenesis in Males but Not Females ncbi.nlm.nih.gov/pmc/articles/PMC6736050/
DHT is linked to increased muscular hypertrophy >Androgens interacts with exercise through the mTOR pathway to induce skeletal muscle hypertrophy pubmed.ncbi.nlm.nih.gov/29472733/
DHT is linked to longer stamina while simultaneously burning more fat during cardio >Role of dihydrotestosterone in whole-body energy utilization during acute running exercise pubmed.ncbi.nlm.nih.gov/30149420/
Liam Walker
tldr: the reason minox reverses hair loss, biologically, is because it suppresses both DHT and T androgen receptors. This wasn't previously thought to be possible but new research since 2017 shows that minoxidil indeed lowers testosterone (and not just DHT:T conversion, though it does that too).
People talk about fin being a "tranny drug" because it suppresses androgens to reverse hairloss, but minoxidil does the exact same thing! Fin and minox work by LITERALLY turning you into a woman.
On the flip side...
>The effects of creatine and creatine plus beta-alanine on strength, power, body composition, and endocrine changes were examined during a 10-wk resistance training program in collegiate football players. Thirty-three male subjects were randomly assigned to either a placebo (P), creatine (C), or creatine plus beta-alanine (CA) group. [...] Resting testosterone concentrations were elevated in C. pubmed.ncbi.nlm.nih.gov/17136944/
>Levels of DHT and T increased by 56% after 7 days of creatine loading and remained 40% above baseline after 14 days maintenance (P < 0.001). The ratio of DHT:T also increased by 36% after 7 days creatine supplementation and remained elevated by 22% after the maintenance dose (P < 0.01). >pubmed.ncbi.nlm.nih.gov/19741313/
Creatine INCREASES testosterone. It is also well known that creatine also can accelerate hairloss. Hairloss, by connection with our minox/fin and creatine findings, is linked to higher testosterone biologically. Thus, we can assume bald men were sexually selected for over time for reproductive capability. In short, only little boys and low test "men" have their hair into their late 20s/30s, quite literally speaking. If you don't have a receding hairline, you're not a man.
/thread
Charles Mitchell
Now explain why there's a whole host of retards over at r/minoxbeards slathering this shit on their face getting results if it's an androgen suppressant. Testosterone and its derivatives need to bind to a hair follicle to mature it.
Adam Watson
Because it matures facial hair follicles by some other mechanism?
Lucas Gonzalez
The substance is a blood thinner, hair follicles will only mature from vellus to terminal if androgen hormones bind to the root. Thinner blood means there's more of a chance for test to bind to the hair. FtM trannies use this stuff in conjunction to their testosterone meds and they still end up with full facial/body hair. Stop being a falseflagging faggot.
Jace Campbell
Go shill somewhere else you feel mongering kike
Minox has been used for treeting hairloss since 1988, and it's mechanism behind improving hairloss is widely unknown. If minoxidil's mechanism was as simple as suppressing testosterone, this fact would already be widely known.
Also, some sides of minox include INCREASED test, and extra growth of hair all around the body.
You are trying to shill poor newfags creatine, which some studies and anecdotal evidence show increases DHT (WHICH IS THE ROOT CAUSE TO MPB)
They're all setting themselves up for a big fall. Desperation makes people foolish.
Nicholas Price
So if I take viagra daily will my beard gains increase?
Justin Myers
Minox works because it increases subdermal blood flow to the follices, it doesn't "mature" vellus hair as much as supply bloodflow to dormant follices. The method which it acts upon (up until recently) was thought to not involve testosterone at all. However recent research (see ) has shown that minox actually has the same side effects that fin does (ie, not suppresses DHT, which promotes hairgrowth) but downregulate ALL androgen receptors (thus making DHT and T less effective and decreasing total serum androgen). are you retarded? the linked research from 2015, 2017 and now a clinical review in 2020 has shown that minox DOES affect androgen sensitivity, to both DHT and T (see ). You're literally taking a tranny drug which lowers your total androgens. previously it was thought that minox was same and had no hormonal effect but this is not the case.
Gabriel Gutierrez
It must not be very significant impact on androgens, since you can get a beard and chest hair from rubbing it there
Jaxon Wilson
do people even take minox internally? I don't understand what the point of any of this is.
Elijah Wilson
>dihydrotanshinone 1
user did you even read the titles lol
Jace Peterson
again, if you read the research, the method of action for minoxidil to cause hair growth is related to increasing blood flow, no testosterone is involved. Only recently was it discovered that minox has the same negative affect on total androgen as finasteride. There's increasing reports of young guys suffering severe sexual dysfunction from topical minox, especially to try to grow a beard.
If you want to attempt hair growth, your best natural bet is dermarolling and maybe topical peppermint or jojoba or castor oil. Stay away from fin/minox.
Matthew Taylor
Don't care, I started using it a couple of days ago for beard gains. Honestly I don't believe in side effects anymore, I've been on all kinds of shit including two years of SSRIs and I never got any of the negative effects advertised with any medicine. I'll take my chances no (not usually) but it still gets absorbed by your skin and enters your bloodstream
Christian Nelson
Yes, but the negative effects of minoxidil that they studied were found even through topical administration. Also on your face (where a lot of zoomies are putting it now) it enter your blood very quickly and has far more absorption than scalp administration
Matthew Jackson
in what degree assuming oral is 100% or close to it?
Xavier Wilson
>if you do your research!!! >studies show!!! >experts say!!!
bald fags are suurreee getting desperate justifying letting themselves go bald when there are DOZENS of treatments that work with ZERO sides.
>y-you're making it up!! >Our characterization of the relationship between minoxidil and AR [androgen receptivity] showed that minoxidil interferes with AR-related functions, decreasing AR transcriptional activity, reducing expression of targets at the protein level, and suppressing AR-positive LNCaP cell growth. Furthermore, our mechanistic studies showed that the suppressive effect of minoxidil on AR-related functions reflected its ability to directly bind to the AR; interfere with AR-peptide, AR-coregulator and AR N-C interactions; and reduce AR protein stability.
