This is my fisrt playthrough, what do I do next?
Factorio
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autism
Now build THE CENTRIFUGE
Make a bus
Research new stuff, build factories to make things you need to research new stuff, lose your mind over trains and oil.
This game is really fun right now but I don't think I have enough brain power to build that.
Should I have multiple bases or try to just have one main base?
Expand production, make more things at once, mine more resources at once, THE FACTORY MUST GROW
But seriously, the biggest tip I can give is that you should automate the production of things like inserters, assembling machines, electric poles, belts, everything you need to make the factory bigger. It will be much easier to expand if you can just run over and pick up the things you need rather than handcrafting things like assemblers.
build a belt with iron gears and green circuits and make a basic mall that produces the belts, the inserters, electric miners and anything you need.
If you're just playing normally and not doing megabase autism grids you won't really need more than one base where you funnel all the resources, but it's up to you. It's fine to stay on one spot until you've mined everything there, which is gonna take some time at first before the raw material consumption gets out of hand and you have to expand. You'll know when you have to scale up your smelting and organize remote mining outposts and by that time you'll probably have everything ready for some basic trains.